NSAIDs are contraindicated or used with caution in which common GI condition?

• A. Peptic ulcer disease
• B. Duodenitis
• C. Gastritis
• D. Gastric adenocarcinoma

Answer: (A)

NSAIDs inhibit protective prostaglandins in the stomach, which reduces the mucus and bicarbonate that guard the lining and lowers mucosal blood flow. This makes existing ulcers more likely to bleed or perforate and can impair healing. Because of this, peptic ulcer disease is the situation where NSAIDs are contraindicated or used with caution, often with gastroprotective strategies if NSAIDs are absolutely needed.

Gastritis and duodenitis can be aggravated by NSAIDs since they irritate the mucosa, but they aren’t the classic, highly contraindicated scenario like an established ulcer. Gastric adenocarcinoma isn’t a standard contraindication to NSAIDs; pain management in the setting of cancer requires careful consideration of bleeding risk and interactions, but it’s not the typical reason for avoiding NSAIDs.