What is the typical adult dose of ibuprofen for rheumatoid arthritis?

• A. 800 mg twice daily
• B. 400 mg orally 3 times a day
• C. 200 mg every 6 hours
• D. 600 mg four times daily

Answer: (B)

Dosing ibuprofen for rheumatoid arthritis is about providing enough anti-inflammatory exposure with divided doses while keeping safety in mind. A typical adult starting regimen is 400 mg by mouth three times daily, which gives a steady level of anti-inflammatory effect without hitting the higher per-dose amounts that raise GI and kidney risks. Higher doses like 600 mg four times daily reach about 2400 mg per day, which can be used under supervision but offers no clear advantage for most patients and increases adverse effect risk. Very small or infrequent dosing (such as 200 mg every 6 hours or only 800 mg per day) generally isn’t sufficient to control inflammation long-term. Therefore, 400 mg three times daily best reflects standard practice for rheumatoid arthritis, with adjustments made by a clinician based on tolerance and response (keeping within the overall daily maximum if continued long-term).