Which agent is a uricosuric drug used to increase uric acid excretion?

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Multiple Choice

Which agent is a uricosuric drug used to increase uric acid excretion?

Explanation:
This question tests how uric acid is handled by the kidney and how certain drugs alter that handling. Probenecid is the uricosuric agent. It inhibits the urate transporter in the proximal tubule (URAT1), which normally reabsorbs filtered uric acid back into the bloodstream. By blocking this reabsorption, more uric acid stays in the urine and is excreted, lowering circulating uric acid levels. In contrast, allopurinol reduces uric acid production by inhibiting xanthine oxidase, while colchicine and NSAIDs address inflammation and pain rather than uric acid handling.

This question tests how uric acid is handled by the kidney and how certain drugs alter that handling. Probenecid is the uricosuric agent. It inhibits the urate transporter in the proximal tubule (URAT1), which normally reabsorbs filtered uric acid back into the bloodstream. By blocking this reabsorption, more uric acid stays in the urine and is excreted, lowering circulating uric acid levels.

In contrast, allopurinol reduces uric acid production by inhibiting xanthine oxidase, while colchicine and NSAIDs address inflammation and pain rather than uric acid handling.

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